Several cities have seen major investments both in research infrastructure and trained scientific manpower people in establishing high-end institutions in the scientific and echnological sector. Similarly, knowledge industry has also grown as enterprise in these cities. Yet, the connect between R&D institutions, academia, including state universities and industry is weak. The aim of the city cluster is to provide a platform to leverage the complementary strengths through effective collaboration and cooperation by developing a functional connect. The clusters will serve as hubs, which will interact with the broader city ecosystem including the state university, colleges, medical schools and local administration. Another major effort involves the development of research programmes in the state university system by providing the enabling eco-system.