The Office of the Principal Scientific Adviser to the Government of India is contributing towards building a healthier and resilient India through scientific advisory to shape the National One Health Mission. Recognizing the interconnectedness of human, animal, and environmental health sectors, the mission aims to enable a coordinated action across sectors to prevent, detect, and respond to health threats. Approved by the Prime Minister’s Science, Technology and Innovation Advisory Council (PM-STIAC), led by the OPSA, and implemented by the Indian Council of Medical Research (ICMR), the mission unites ministries and scientific institutions to boost integrated disease surveillance, early warning, research collaboration, laboratory networks, and pandemic readiness. This coordinated framework accelerates data sharing, capacity building, and joint response planning to ensure faster and more effective interventions when risks emerge. The Mission is complemented through other initiatives of science-based regulation of medical products and devices to support patient safety, quality assurance, innovation, and indigenous manufacturing; and the National Plant Health Initiative to protect crops and biodiversity through better surveillance, diagnostics, sustainable agriculture, and biosecurity. Together, these initiatives are reshaping the approach to health by linking research, regulation, agriculture, and governance to build a healthier, safer and more resilient nation under the One Health framework. Dr (Mrs.) Parvinder Maini | Sangeeta Agarwal | Hafsa Ahmad | Dr Sindura Ganapathi | Arundhati Mohanty | Darshan Narayan